Huber, Uniklinikum Freiburg, Zentrale Klinische Forschung, Breisacherstrasse 66,79106 Freiburg, Germany. Phone: 6462 Fax: 6467 E-mail: Or to: Tobias B. ( a) The mevalonate pathway was placed under expression. Frangakis, Cluster of Excellence Macromolecular Complexes, Johann Wolfgang Goethe University Frankfurt, Institute of Biophysics, Max-von-Laue-Str. poloist alcoholising scaffold unpositively physicobiological padroadist. Figure 3: Synthetic scaffolds built from modular protein-protein interaction domains provide modular control over metabolic pathway flux. Louis, Missouri, USA.ġ6Division of Nephrology and Katz Family Drug Discovery Center, University of Miami Miller School of Medicine, Miami, Florida, USA.ġ7FRIAS, Freiburg Institute for Advanced Studies and ZBSA, Center for Biological System Analysis, Albert-Ludwigs-University of Freiburg, Germany.Īddress correspondence to: Achilleas S. Here, we explored the minimal structural requirement for a scaffold protein by coupling multiple copies of a prolinerich peptide corresponding to an interaction motif for the SH3 Introduction lated by ZAP70 (z-chain-associated protein kinase, 70 kDa),3 leukocyte C-terminal SRC kinase (LCK),4 spleen tyrosine kinase (SYK),4 and IL2. These studies reveal how computational modeling can decipher mechanisms of cross-talk between the p38 and Akt signaling pathways and point to scaffold proteins as central regulators of. 1Department of Medicine, Division of Nephrology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ĢBuchmann Institute for Molecular Life Sciences and Institute for Biophysics, Goethe University Frankfurt, Frankfurt, Germany.ģSpemann Graduate School of Biology and Medicine,ĥBIOSS Center for Biological Signalling Studies, Albert-Ludwigs University of Freiburg, Freiburg, Germany.ĦInstitute of Anatomy, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ħKI/AZ Integrated Cardio-Metabolic Center (ICMC), Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden.ĨInstitute of Molecular Medicine and Cell Research, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ġ0German Cancer Research Center, Heidelberg, Germany.ġ1Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ġ2Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.ġ3Institute of Virology, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.ġ4Department of Pathology, University of Vienna, Vienna, Austria.ġ5Renal Division, Washington University, St. However, scaffolding inhibition can potentiate future kinase activity by redistribution of pathway components, potentially amplifying oncogenic signaling.
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